Phylo

Biomni Lab

Research

We push the frontier of AI to build biomedical super-intelligence.

We believe in open science — all of our core research is open source.

Biomni: A General-Purpose Biomedical AI Agent

Jun 2, 2025

biorxiv

The original Stanford paper introducing open-source Biomni by Phylo's founding team.

GitHub →

Biomni: A General-Purpose Biomedical AI Agent

Jun 2, 2025

The original Stanford paper introducing open-source Biomni by Phylo's founding team.

GitHub →

Biomni: A General-Purpose Biomedical AI Agent

Jun 2, 2025

biorxiv

The original Stanford paper introducing open-source Biomni by Phylo's founding team.

GitHub →

Sep 2, 2025

Biomni-R0: Using RL to Hill-Climb Biomedical Reasoning Agents to Expert-Level

We apply end-to-end reinforcement learning to Biomni agent, creating rewards and RL environments tailored to biomedicine, scalably training the agent to carry out research tasks more effectively.

GitHub →

Sep 2, 2025

Biomni-R0: Using RL to Hill-Climb Biomedical Reasoning Agents to Expert-Level

We apply end-to-end reinforcement learning to Biomni agent, creating rewards and RL environments tailored to biomedicine, scalably training the agent to carry out research tasks more effectively.

GitHub →

Sep 2, 2025

Biomni-R0: Using RL to Hill-Climb Biomedical Reasoning Agents to Expert-Level

We apply end-to-end reinforcement learning to Biomni agent, creating rewards and RL environments tailored to biomedicine, scalably training the agent to carry out research tasks more effectively.

GitHub →

Jul 30, 2025

CRISPR-GPT for agentic automation of gene-editing experiments

We present CRISPR-GPT, an LLM agent system to automate and enhance CRISPR-based gene-editing design and data analysis. CRISPR-GPT leverages the reasoning capabilities of LLMs for complex task decomposition, decision-making and interactive human–artificial intelligence (AI) collaboration.

GitHub →

Jul 30, 2025

CRISPR-GPT for agentic automation of gene-editing experiments

GitHub →

Jul 30, 2025

CRISPR-GPT for agentic automation of gene-editing experiments

GitHub →

Jul 17, 2025

Automated Hypothesis Validation with Agentic Sequential Falsifications

Here we introduce POPPER, an agentic framework for rigorous automated validation of free-form hypotheses. Guided by Karl Popper's principle of falsification, Popper validates a hypothesis using LLM agents that design and execute falsification experiments targeting its measurable implications.

GitHub →

Jul 17, 2025

Automated Hypothesis Validation with Agentic Sequential Falsifications

GitHub →

Jul 17, 2025

Automated Hypothesis Validation with Agentic Sequential Falsifications

GitHub →

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Research

Publication

Links

September 2, 2025

9/2/25

Sep 2, 2025

Date

Biomni-R0: Using RL to Hill-Climb Biomedical Reasoning Agents to Expert-Level

Research

Biomni blog

Publication

Paper →

Links

July 30, 2025

7/30/25

Jul 30, 2025

Date

CRISPR-GPT for agentic automation of gene-editing experiments

Research

Nature Biomedical Engineering

Publication

Paper →

Links

July 17, 2025

7/17/25

Jul 17, 2025

Date

Automated Hypothesis Validation with Agentic Sequential Falsifications

Research

ICML 2025

Publication

Paper →

Links

June 2, 2025

6/2/25

Jun 2, 2025

Date

Biomni: A General-Purpose Biomedical AI Agent

Research

biorxiv

Publication

Paper →

Links

December 17, 2025

12/17/25

Dec 17, 2025

Date

Evaluating Large Language Models in Scientific Discovery

Research

arxiv

Publication

Paper →

Links

September 3, 2025

9/3/25

Sep 3, 2025

Date

BioLab: End-to-End Autonomous Life Sciences Research with Multi-Agents System Integrating Biological Foundation Models

Research

biorxiv

Publication

Paper →

Links

June 2, 2025

6/2/25

Jun 2, 2025

Date

Toward Scientific Reasoning in LLMs: Training from Expert Discussions via Reinforcement Learning

Research

arxiv

Publication

Paper →

Links

April 28, 2025

4/28/25

Apr 28, 2025

Date

A call for built-in biosecurity safeguards for generative AI tools

Research

Nature Biotechnology

Publication

Paper →

Links

September 25, 2024

9/25/24

Sep 25, 2024

Date

A Foundation Model for Clinician-centered Drug Repurposing

Research

Nature Medicine

Publication

Paper →

Links

May 23, 2023

5/23/23

Date

Uncertainty Quantification over Graph with Conformalized Graph Neural Networks

Research

NeurIPS 2023, Spotlight

Publication

Paper →

Links

August 18, 2022

8/18/22

Aug 18, 2022

Date

Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles

Research

Molecular Cell

Publication

Paper →

Links

February 10, 2022

2/10/22

Feb 10, 2022

Date

dCas9-based gene editing for cleavage-free genomic knock-in of long sequences

Research

Nature Cell Biology

Publication

Paper →

Links

September 21, 2022

9/21/22

Sep 21, 2022

Date

TDC: Artificial Intelligence Foundation for Therapeutic Science

Research

Nature Chemical Biology

Publication

Paper →

Links

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We push the frontier of AI to build biomedical super-intelligence.

We push the frontier of AI to build biomedical super-intelligence.

We push the frontier of AI to build biomedical super-intelligence.

Biomni: A General-Purpose Biomedical AI Agent

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Join us in building the best agentic intelligence for biology

Join us in building the best agentic intelligence for biology

Join us in building
the best agentic intelligence for biology

Join us in building
the best agentic intelligence for biology